Caralluma has undergone two human double blind, randomized, placebo controlled human clinical trials. Caralluma safety has been reviewed by three toxicology studies done per exacting OECD guidelines and has achieved self-affirmed GRAS [Generally Recognized As Safe] status. I believe that Caralluma is safe to consume at the recommended dosage.
Indian tribes chew chunks of Caralluma Fimbriata to suppress hunger when on a day's hunt. This succulent is used amongst the labor classes in South India to suppress appetite and enhance endurance. Wealth of India, the Indian Health Ministry's comprehensive compilation on medicinal plants, lists Caralluma Fimbriata as a vegetable and as a famine food. The key phytochemical constituents of the herb are Pregnane Glycosides, Flavone Glycosides, Megastigmane Glycosides, Bitter Principles, Saponins etc.
 
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